A major breakthrough in science! Exercise causes the liver to produce anti-aging proteins! The blood of the individual who moves can make the brain younger!

July 14, 2020 /PRNewswire/ -- It is well known that exercise can make thinking sharper: Exercisers and mice perform better on cognitive tests, and older people who exercise regularly have a lower risk of developing dementiaNow, in a surprising discovery, researchers report that the blood of regular exercise mice can activate the brains of sedentary micerecently published in Science, the article entitled "Blood factors transfer effect s ei lys of exercise on neurogenesis and cognition to the aged brain"this effect can be traced back to a special liver protein in the blood that provides an old or weak drug that allows the brain to benefit from exercise, for those who rarely leave a chair or bed"Does your brain think you're exercising just because of something in your blood?" Saul Villeda, an aging researcher at the University of California, San Francisco (UCSF), who led the rodent study, askedthe study, which is based on studies in Villeda's and other laboratories, showed that the blood of young mice could rejuvenate the brains and muscles of older micesome research groups claim to have found specific proteins that could explain the benefits of this "young blood", DrAlana Horowitz and postdoctoral student Xuelai Fan of villeda wanted to know whether exercise -- not just young bodies -- could bring similar benefits through bloodpicture source: SHAPECHARGE is an easy test: Researchers put a wheel in a cage full of mice, and most inactive animals run for miles at nightresearchers collected blood from middle-aged and elderly mice with wheels in their cages for six weeks and then pumped them onto older mice without wheels in the cagemice that received the blood eight times in three weeks performed almost as well on learning and memory tests, such as navigating in a mazeanother group of "TV fans" received the same old, non-athletic mice' blood, with no significant improvementvilleda's team recently reported in Science that mice that get blood from active mice also grow about twice as many new neurons in the hippocampus, the area of the brain responsible for learning and memorythis change is similar to that of directly moving rodents, the researchers looked for proteins that rose in the blood of mice, and the researchers found that the proteins were produced in the livers of mice called glycogenphosphate inositol-specific phospholipidseDase D1 (Gpld1)scientists injected the Gpld1 gene into the tail veins of TV-obsessed mice, transporting the gene to their livers to produce the enzymeAfter3 weeks, the rodents' cognitive abilities and brain neuron growth improved significantly, as did the blood input therapy in the mice they exercisedteam also found that gpld1 blood levels in older people who exercised regularly were significantly higher than those who did not exercise, suggesting that the results of the mice's experiments may also apply to humanshowever, the researchers did not find much Gpld1 in the brains of the moving mice, suggesting that it did not appear to have crossed the blood-brain barrier, instead, its role in promoting the brain may come from isolating certain other proteins from many types of cell membranesthese released molecules then enter the bloodstream, reducing inflammation and clotting processes associated with Alzheimer's disease and cognitive declineVilleda's team now hopes to find a drug similar to this effect and use it in older people who are weak and unable to exercise"It's very tempting," said Coleen Murphy, a molecular biologist at Princeton University who studies worm aging"We've always wanted people to exercise more, but not everyone can do it, "would be great to be able to provide this benefit to people in the form of pillsWillard Freeman, an aging scientist at the University of Oklahoma City,, believes that such treatments -- even the blood of people who exercise -- can also help young people who are recovering who can't exercise, and he sees seriously injured soldiers as veterans' affairs researchers, however, he warned that Villeda's team had only found part of a chain of events"We still have a lot to learn and study,"" () Source: "1) Protein from the resources of the brains of the chowing mice rejuvenates of the "couch potato" mice 2" blood factors transfer siee effects of the exercise on neurogenesis and thes of the brain " 3" Protein