A high-salt diet caused cognitive impairment in the brain in mice

Heavy taste" diet has become a daily choice for most people, but a mouse study published in the British journal
on the 14th found that a high-salt diet can affect brain health - causing changes in the gut immune system that can lead to cognitive impairments, and lifestyle changes that could reverse the effect.
a high-salt diet is known to cause elevated blood pressure in humans and increase the risk of cardiovascular disease. At the cellular level, excessive salt intake can lead to abnormal function of endoth endoblasts (covering the inner surface of blood vessels and regulating vascular stress), but the long-term effects of this abnormality on different organs have long been unclear.
team at the Weill Cornell School of Medicine in the United States this time asked mice to eat a high-salt diet -- comparable to the high-salt ratio in some human diets. After a few weeks, the mice had abnormal endoblasts, reduced cerebral blood flow, and cognitive impairment in multiple behavioral tests, but no change in blood pressure. A high-salt diet also increased the number of TH17 white blood cells in the intestines of mice and raised levels of an inflammatory molecule (IL-17) released by these cells. The researchers found that it was the increase in IL-17 in blood flow that led to the negative effects of a high-salt diet on cerebrovascular function and behavior.
although these are based on mouse experiments, they also suggest that IL-17 can affect human cerebrovascular endothystic cells in a similar way, meaning that a high-salt diet may have a negative impact on human brain health. It is important to note that a return to a normal diet in mice or through drug intervention can reverse the consequences of a high-salt diet, i.e. lifestyle changes or the development of new prescription drugs, which are expected to prevent or help reverse the consequences. (Source: Science and Technology Daily Zhang Mengran)