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The lack of NEGR1 may cause pre-diabetes in mainly male mice
Obesity and diabetes are increasingly serious international problems in recent years
In 2019, 463 million people worldwide were diagnosed with diabetes, and 374 million people were at risk of developing type 2 diabetes
Researchers suspect that the gene that causes diabetes is Negr1
In the experiment, mice of both sexes were used, which has never been done in previous similar studies
In the glucose tolerance test, the glucose tolerance of mice without Negr1 was much lower than that of mice with Negr1, and they reached a pre-diabetic state
Since Negr1 promotes depression and schizophrenia, its effect on body weight has so far been considered a side effect of mental disorders
There is still no reason to despair
In summary, it can be said that NEGR1 protein affects body weight, appetite and mental health, including the development of diabetes and mental illness
Original search:
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
DOI
10.
