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A deadly combination: discovering a new direct cause of cell death

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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It is well known that the so-called "apoptosis-enforcing protein" BAX encounters DRP1 on the mitochondrial membrane of cells

BAX is a key protein in the cell death pathway

"When we artificially force these two proteins to interact, they move from the cytoplasm to the mitochondria, where the protein complex triggers the reorganization of the mitochondria

Combining methods such as dimerization-dependent fluorescence techniques, cross-linking mass spectrometry, and analysis of different protein fragments, the interacting surfaces were also identified for the first time

Work on this study began at the Interfaculty Institute for Biochemistry in Tübingen, Germany, and was completed at the CECAD Research Center of the Institute of Genetics in the Garcia-Seth laboratory

Journal Reference :

Andreas Jenner, Aida Peña‐Blanco, Raquel Salvador‐Gallego, Begoña Ugarte‐Uribe, Cristiana Zollo, Tariq Ganief, Jan Bierlmeier, Marcus Mund, Jason E Lee, Jonas Ries, Dirk Schwarzer, Boris Macek, Ana J Garcia ‐Saez.

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