-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
A discovery led by the University of California, Irvine has propelled the search for improved treatments
The GLI1 protein, the subject of this study, is critical for cell development but is also implicated in some cancers
"In some cases, a protein in one pathway can turn on a protein in another pathway," said A.
GLI1 normally forms strong bonds with a protein called SUFU
"We identified three that can be phosphorylated and involved in weakening the binding between GLI1 and SUFU," said Lee Bardwell, a professor of developmental and cell biology whose lab conducted the project
He noted that phosphorylation at all three sites resulted in significantly higher levels of GLI1 escaping from SUFU compared to just one or two accepting phosphate groups
The discovery is an important step toward more effective and personalized cancer treatment
references:
