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The regenerative repair of large tissue defects inhas always been a difficult problem for clinicians, and the team of Professor Jiang Xinquan of the Ninth People's Hospital, affiliated with Shanghai Jiaoxuan University School of Medicine, found that selective magnesium transport protein-1 (MagT1) is closely related to the bone-forming process in mouse embryo cartilage, and then put forward a strategy to simulate the development of bone microentomas in a local high magnesium environment.
results were published online in the international journal Advanced Science in the form of cover articles.
Through the study of bone development in fetal mice, the team found that selective magnesium transport protein-1 (MagT1) was closely related to the bone-forming process in mouse embryo cartilage, and then proposed a strategy to simulate bone development micro-environment to promote angiogenic bone regeneration in a local high magnesium environment. The research innovatively selected magnesium ions for constructing the optimal concentration of angiogenic bone regeneration micro-environment under the guidance of MagT1 expression, successfully prepared a high magnesium stem cell micro-ball carrier in combination with sodium sea alginate, and achieved remarkable angiogenic bone regeneration effect in animal models.
experts say the study's bone-like development regeneration strategy offers new ideas for bionic design of biological materials.
it is learned that Jiang Xinquan's team has long been committed to the research and transformation of the regeneration and repair of soft and hard tissues of the jaw face, and has made many progress in the clinical problem of angiogenesic regeneration of large bone defects. This is the first time that the team master's student has published an original thesis in Advanced Science with the first author, and the doctoral students Yang Guangzheng and Dr. Zhang Wenjie are the co-first and co-communicative authors of the thesis, respectively. (Source: Science Network Xu Ying Huangxin)
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