230,000 studies confirmed the risk of serrated polyps raising the risk of colon cancer, and Professor Huang Xiaojun led the JCO article. Tumor intelligence.

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Key points: CA: 230000 people have confirmed that serrated polyps increase the risk of colorectal cancer. JCO: antithymocyte globulin (ATG) is effective in preventing acute graft-versus-host disease (aGVHD). Jto: guidelines for diagnosis and management of patients with pulmonary neuroendocrine tumors Chinese Journal of oncology: consensus of clinicopathologists on detection of PD-L1 expression in non-small cell lung cancer in China The journal updated the perspectives column online to report the results of a large retrospective study published on July 7 in gastroenterology, providing more accurate information on the relationship between serrated polyps (SP) and the risk of colon cancer.the cover screenshot of the article (the full text is obtained by Xiaobian wechat YXJ Oncology) research investigated more than 230000 people who had undergone colonoscopy, and classified the patients' serrated polyps according to their size and location. The median follow-up time was 3.6 years. It was found that the cumulative incidence of colorectal cancer per 1000 people at 5 years and 10 years after colonoscopy was: polyp free: 1.2 (95% CI) at 5 years 1.0-1.4) and 4.7 (95% CI 4.0-5.6) at 10 years.proximal small SP: 2.5 (95% CI 1.4-4.3) at 5 years and 14.8 (95% CI 9.0-24.3) at 10 years.proximal large SP: 6.2 (95% CI 2.3-17.0) at 5 years and 30.2 (95% CI 13.2-68.4) at 10 years.distal SP: 1.7 at 5 years (95% CI 1.1-2.6) and 5.9 at 10 years (95% CI 3.6-9.5).proximal SP with adenoma: 4.2 at 5 years (95% CI 2.9-6.3) and 26.0 at 10 years (95% CI 16.1-42.0).distal SP with adenoma: 3.0 at 5 years (95% CI 2.0-4.5) and 12.1 (95% CI 6.2-23.5) at 10 years."our findings in this study confirm our hypothesis that proximal SP, especially in the large intestine, is associated with an increased risk of colorectal cancer and therefore deserves close monitoring. "In addition, our findings support the current usmstf recommendations, including three-year colonoscopy for large sessile SPS and lower frequency for small sessile SPS," the authors said."serrated polyps (inside picture) doi:: antithymocyte globulin (ATG) is effective in preventing acute graft-versus-host disease (aGVHD). On July 10, JCO magazine updated online the results of a clinical study from China entitled" Application of antithymocyte globulin in blood transplantation from sibling donors: a multicenter, open label, randomized controlled study ", Beijing Professor Huang Xiaojun, Department of Hematology, people's Hospital of University, is the corresponding author.this study recruited 263 HLA matched sibling donors from multiple centers across the country. They were randomly assigned to ATG group (ATG 4.5mg/kg plus cyclosporin, methotrexate and mycophenolate mofetil) and control group (without ATG). Compared with the control group, the cumulative incidence of grade 2-4 aGVHD was significantly reduced (13.7% vs) There were no significant differences in 3-year recurrence free mortality, 3-year cumulative relapse rate, 3-year leukemia free survival rate and EB virus activation rate.the authors said: "this study is the first prospective randomized controlled study in the field, confirming that ATG can effectively reduce the incidence of aGVHD after sibling donor transplantation, and does not affect the 3-year cumulative recurrence rate and non recurrence mortality rate."doi: 10.1200/jco.20.00150 Journal of clinical oncology 03jto: guidelines for the diagnosis and management of patients with pulmonary neuroendocrine tumors updated on July 11, jto magazine updated the best practice guidelines for pulmonary neuroendocrine tumors developed by the Commonwealth collaboration for neuroendocrine tumor research (commnets) and the North American Society of neuroendocrine Oncology (NANETS).the working group screened 230 out of 1109 publications for inclusion in this guide, approved 12 statements, revised or updated 22 articles, deleted 1 article and added 2 articles.the authors said: "the updated patient guidelines for the treatment of local and metastatic pulmonary neuroendocrine tumors contain the latest evidence and aim to unify the global treatment for patients with lnet.China China official account of PD-L1 expression in non-small cell lung cancer (
) published in July 12th. The official public issue of Chinese Journal of cancer was published by the China Cancer Association, Specialized Committee, the China Society of Clinical Oncology, and the Chinese Academy of Clinical Oncology, the non-small cell lung cancer expert committee of the Chinese society of Clinical Oncology (DOI:). "Consensus of clinical pathology experts on detection of PD-L1 expression in non-small cell lung cancer in China", corresponding authors are professor Ying Jianming and Professor Wang Jie from Cancer Hospital of Chinese Academy of Medical Sciences. consensus points out that detection of PD-L1 expression can be used as an adjunct diagnosis to guide the treatment decision-making of PD-1 and / or PD-L1 monoclonal antibody drugs, and can also be used as a supplementary diagnosis to help screen potential beneficiaries of immunotherapy. in clinical practice, PD-L1 expression, tumor mutation load (TMB) and microsatellite instability (MSI) are independent of each other. high microsatellite instability (MSI-H) in lung cancer is very rare. PD-L1 expression and TMB are mainly detected in clinical practice. considering that the detection of PD-L1 expression is simple and convenient, while TMB is relatively complex and expensive, it is recommended to detect PD-L1 first and then TMB; if possible, PD-L1 and TMB can be detected at the same time. full text link: 05 social news: the 6th grade students won the colorectal cancer gene research award. On July 12, a sixth grade student of Panlong primary school in Kunming City, Yunnan Province, won the National Youth Science and Technology Innovation Award by studying the function and mechanism of mutation gene in the occurrence and development of colorectal cancer, which was widely spread in social media. the relevant experimental records in the gene experiment report of Chen Lingshi. source / the official website of the National Youth Science and technology innovation competition. According to the project on the official website, this project analyzed the genome and transcriptome of plateau domestic mammals and corresponding plain species by genetic comparison, found the key mutation gene c10orf67 selected for hypoxia adaptation of plateau mammals, and constructed c10orf67 gene knockout mice, and found that c10orf67 was highly expressed in colorectal cancer Knockdown of its expression can significantly inhibit cell proliferation and arrest cells in G2 / M phase. further studies have shown that c10orf67 can regulate the sensitivity of colorectal cancer cells to chemotherapeutic drugs. therefore, the functional analysis of c10orf67 in colorectal cancer is expected to provide new biomarkers and drug targets for the diagnosis and treatment of colorectal cancer. some netizens pointed out that such a scientific research level is far beyond the cognitive scope of a sixth grade primary school student. "There must be serious academic corruption behind it, calling for strict investigation. "on July 13, the relevant person in charge of Yunnan Association for science and technology told relevant reporters that they had noticed the public concern about Chen's gene research. ▍ we have seen it through and voted for: reference [1] Fillon, M. proximal serialized polymers increase the future risk of chromatic cancer. CA cancer J Clin. 2020. Huang et al. Antithymocyte globulin for matched sibling donor transformation in patients with hematological malignancies: a multicenter, open label, Randomized Controlled Study. Journal of Clinical Oncology DOI: 10.1200/JCO.20.00150 Journal of Clinical Oncology Published online July 10, 2020. [3]Simron Singh et al, CommNETs/NANETS guidelines for the diagnosis and management of patients with Lung Neuroendocrine Tumors: An international collaborative endorsement and update of the 2015 ENETS expert consensus guidelines. Journal of Thoracic Oncology.  Published:July 11 , 2020 doi: Cancer Pathology Committee of China Anti Cancer Association, tumor pathology Expert Committee of Chinese society of Clinical Oncology, expert committee of non-small cell lung cancer of Chinese society of clinical oncology. Consensus of clinical pathology experts on detection of PD-L1 expression in non-small cell lung cancer [J]. Chinese Journal of oncology, 2020, 42(7):513-521. DOI:10.3760/cma.j.cn112152-20200313-00202. [5] Study on the function and mechanism of c10orf67 in the occurrence and development of colorectal cancer