1p19q Correlation with chromosomal polysaccosis and prognosis of common missing glioblastoma

Hui Chen of the Department of Pathology at Kettering Cancer Center in New York, USA, and others studied the effects of chromosomal polysacwason on the prognosis of patients with 1p19q total loss of less protocytosisThe results were published online in May 2019 by Neuro-Oncology- Excerpted from the articleRef: Chen H,et al.
Neuro Oncol.2019 May 29pii: noz098doi: 10.1093/neuonc/noz098Molecular detection ofless protoscoccal glioblastoma found that 1p19q total deletion and IDH1/2 mutation were good omenschromosomal distedness was associated with poor prognosis in a small number of patientsHui Chen of the Department of Pathology at Kettering Cancer Center in New York,, and others studied the effects of chromosomal polysaccosis on the prognosis of patients with 1p19q total loss of less protoplacytesresults were published online in May 2019 by Neuro-Oncologythe study was conducted by eight medical institutionsBetween January 1996 and December 2013, fluorescence in situ hybridization (FISH) was used to detect and analyze 412 cases of less progenic glioblastoma, as well as chromosomal multitronization the researchers defined the simultaneous deletion of 1p and 19q in tumor cells as 1p and 19q total deletion, i.e 1p19q total deletion; Chromosomal polysitality refers to the presence of three or more signals in 1p and 19q According to the fish method 1p19q loss and polypolymer determination results, 412 cases were divided into 5 groups: (1)1p19q missing , 30% with polysomal chromosomal chromosome group, 150 cases; (2) 1p19q missing 30% with multibody chromosome group, 45 cases; (3) 1p19q total missing without multi-human chromosome group, 138 cases; (4) 1p19q no missing companion multi-body chromosome group, 30 cases and (5) 1p19q no missing and no multi-body chromosome group 49 cases In slot hybrid images show the existence and absence of multibody A.1p19q total absence is not companion otoidal; B.1p19q total missing with multibody; C.1p and 19q are not missing without polysaccosis; D.1p and 19q are not missing with multibody The red probe represents 1p or 19q, and the green probe represents 1q or 19p in 1p19q of the total loss of less protoscoccal cell tumors, polysaccosis was associated with the deterioration of non-progressive survival (PFS) and overall survival (OS) 1p19q no missing tumor chromosome polysaccoticity has no effect on survival, and the presence of polysacisine in 1p19q non-missing glial tumors does not affect PFS or OS The Kaplan-Meier test showed that the 1p19q total loss of polysacwastomy tumor PFS was shorter (p 0.0001) and longer than 1p19q tumor without polysital tumor (p 0.01) 1p19q total loss of polysaphysical tumor OS is higher than 1p19q no missing tumor (p00.0001), lower than the tumor without polysitousness 1p19q total deletion tumor (p-0.07) There are IDH mutations, 1p19q common deletion with multi-body less protoplasmic small protoplasm glioblastoma, PFS than 1p19q total deletion and no multi-humanity less protoplasmic glioblastoma shorter (p0.01), longer than IDH mutation and 1p19q no missing (p 0.05) Among the less-sudden glioblastomas, there were IDH mutations, 1p19q total loss of non-multicivilos the longest, IDH mutation, 1p19q total loss of companionoids, 1p19q no deletion again (p-0.06) The Kaplan-Meier test showed that the presence of polysaccoticity did not affect PFS (p-0.36) or OS (p-0.75) in 1p19q-free gliotic tumors In the 1p19q total loss of less protoplatic cell tumors, the deletion of 30% or 30%, the degree of polysacsexuality on PFS (p.0.76) or OS (p.0.32) has no effect in 1p19q common lysis, chromosomal polysacwases are an independent factor with shorter PFS Age and excision range are independent prognosis factors for survival Multi-factor analysis showed that PFS and OS in patients with less glioblastoma were independently correlated with fluorescent in situ hybridization patterns (p 0.0001), age (p-0.001) and WHO grading (p 0.001) In 3 fluorescent in situ hybridization models, 1p19q no-miss tumor patients were worse than PFS and OS in 1p19q co-missing (p 0.0001) In tumors with 1p19q conplactions, the presence of polysaccosis was independently associated with the deterioration of PFS (p 0.0001) The study found that the difference in survival rates in terms of sex, pathology diagnosis, Ki67 score, IDH1/2 mutation status, initial new complementary chemotherapy, and tumor sites was not statistically significant , the researchers believe that the presence or absence of chromosomal polysaccosis can be further layered with 1p19q common loss of less protoplasmic cellos, there is a risk of early recurrence in people with polysomality, so closer follow-up and more active treatment options are needed.